Truitt R L, Bortin M M, Rimm A A
Transplant Proc. 1980 Mar;12(1):143-6.
Transplanted immunocompetent cells from CBA (H-2k) mice immunized against individual or pooled lymphoid cells from various allogeneic strains resulted in the elimination of widely disseminated leukemia cells in AKR (H-2k) host mice as measured in a GVL bioassay. In most cases, alloimmunization resulted in reactivity against AKR-L comparable to that observed when CBA donors were specifically immunized with irradiated AKR-L cells. Cells from unimmunized or isoimmunized CBA mice had no detectable GVL reactivity. Alloimmunization caused no increase in the mild GVH reactivity of unimmunized or isoimmunized CBA lymphoid cells transplanted into lethally irradiated nonleukemic AKR hosts; whereas, specific immunization with AKR-LX cells resulted in significantly increased GVH-related mortality.
在GVL生物测定中，将来自用各种同种异体品系的单个或混合淋巴细胞免疫的CBA（H-2k）小鼠的免疫活性细胞移植到AKR（H-2k）宿主小鼠中，可导致广泛播散的白血病细胞被清除。在大多数情况下，同种异体免疫产生的针对AKR-L的反应性与用经辐照的AKR-L细胞对CBA供体进行特异性免疫时观察到的反应性相当。来自未免疫或同基因免疫的CBA小鼠的细胞没有可检测到的GVL反应性。同种异体免疫不会增加移植到致死性辐照的非白血病AKR宿主中的未免疫或同基因免疫的CBA淋巴细胞的轻度GVH反应性；而用AKR-LX细胞进行特异性免疫则会导致与GVH相关的死亡率显著增加。
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