[由于糖转运特异性抑制剂根皮苷和根皮素导致青蛙肌肉纤维中D-木糖转运动力学的变化]
[Change in transport kinetics of D-xylose in frog muscle fibers due to the specific inhibitors of sugar transport phlorhizin and phloretin].
作者信息
Vasianin S I
出版信息
Tsitologiia. 1980 Mar;22(3):296-302.
The phloretin and phlorizin inhibition kinetics of D-xylose transport into muscle fibres of Rana temporaria has been studied. Phlorizin inhibits the entry of D-xylose competitevely and reversibly with Ki = 2.8 . 10(-4)M. Ki =9.8 . 10(-5)M has been attributed for phloretin inhibition. Phloretin inhibition was slightly reversible and depended on the state of muscle fibres. The decree of inhibition of sugar exit did not exceed that of sugar entry into the muscle fibres. The effect of phlorizin (5 . 10(-5) and 1 . 10(-4)M) and phloretin (2 . 10(-4)M) was not additive.
已对根皮素和根皮苷对林蛙肌肉纤维中D-木糖转运的抑制动力学进行了研究。根皮苷以竞争性和可逆性方式抑制D-木糖的进入，其抑制常数Ki = 2.8×10⁻⁴M。根皮素抑制的Ki = 9.8×10⁻⁵M。根皮素的抑制作用略有可逆性，且取决于肌肉纤维的状态。糖流出的抑制程度不超过糖进入肌肉纤维的抑制程度。根皮苷（5×10⁻⁵和1×10⁻⁴M）和根皮素（2×10⁻⁴M）的作用不是相加的。
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