小鼠的管道穿行活动：一种评估药物行为效应的方法。
Tube running activity in mice: a method to evaluate the behavioural effects of drugs.
作者信息
Persson S A, Wahlström G
出版信息
Pharmacol Biochem Behav. 1980 Feb;12(2):259-64. doi: 10.1016/0091-3057(80)90366-4.
A new method to study locomotor activity in mice has been developed. The time it takes for a mouse to run 100 cm in a narrow tube is measured. In the present study the effects of various environmental factors on this tube running activity have been examined. The most important factor was found to be the frequency of testing. With repeated testing the run time was increased, which probably is due to a decrease in exploratory activity. However, tube running seems not to be a specific measure of exploratory activity. Administration of nialamide alone (50-200 mg/kg IP) as well as combined with 5-hydroxy-DL-tryptophan (6.25-25 mg/kg IP) gave a dose measuring 5-hydroxy-tryptamine mediated behaviour.
一种研究小鼠运动活动的新方法已经被开发出来。测量小鼠在狭窄管道中跑100厘米所需的时间。在本研究中，已经检测了各种环境因素对这种管道奔跑活动的影响。发现最重要的因素是测试频率。随着重复测试，奔跑时间增加，这可能是由于探索活动的减少。然而，管道奔跑似乎不是探索活动的特定测量指标。单独给予尼亚酰胺（50 - 200毫克/千克腹腔注射）以及与5 - 羟基 - DL - 色氨酸（6.25 - 25毫克/千克腹腔注射）联合使用，产生了一种测量5 - 羟色胺介导行为的剂量。
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