Pratt C B, Howarth C, Ransom J L, Bowles D, Green A A, Kumar A P, Rivera G, Evans W E
Cancer Treat Rep. 1980 Jan;64(1):11-20.
High-dose methotrexate with leucovorin rescue was used alone or in combination with Adriamycin and cyclophosphamide for the treatment of 27 osteosarcoma patients with measurable indicators of disease. Three patients developed complete responses of measurable lesions, two had partial responses, two had static disease, one had symptomatic improvement, and one had return to normal of physical findings following treatment of a flat bone primary osteosarcoma. While the doses and frequency of administration of high-dose methotrexate differed from those used by previous investigators, these results suggest that aggressive treatment with high-dose methotrexate must be attempted to further evaluate its efficacy as single-agent therapy for osteosarcoma patients not eligible for adjuvant chemotherapy trials.
大剂量甲氨蝶呤联合亚叶酸钙解救疗法单独使用或与阿霉素及环磷酰胺联合使用，用于治疗27例有可测量疾病指标的骨肉瘤患者。3例患者出现可测量病灶的完全缓解，2例部分缓解，2例病情稳定，1例症状改善，1例在治疗扁平骨原发性骨肉瘤后身体检查结果恢复正常。虽然大剂量甲氨蝶呤的给药剂量和频率与先前研究者使用的不同，但这些结果表明，对于不符合辅助化疗试验条件的骨肉瘤患者，必须尝试采用大剂量甲氨蝶呤进行积极治疗，以进一步评估其作为单药治疗的疗效。
