Morse E E, Quinn J, Altman A, Talaizedeh M, Brassel J, Taubman S
Ann Clin Lab Sci. 1980 Mar-Apr;10(2):143-8.
Tartrate resistant acid phosphatase (TRAP) has been demonstrated during relapse in the cells in the cerebral spinal fluid (CSF) in a patient with the clinical features of acute T cell lymphocytic leukemia which suggests this isozyme may be a marker for malignant transformation of some types of lymphocytes. The presence of TRAP may be helpful in establishing the diagnosis of a lymphocytic malignancy since normal lymphocytes appear to have tartrate sensitive acid phosphatase. The presence of TRAP can no longer be considered specific for hairy cell leukemia, since children with acute lymphocytic leukemia are being found with this isozyme in their malignant blasts. The presence of TRAP does not appear to be specific for T or B cell lines of malignant lymphocytes since it has been described in cells with either type of cell markers. The presence of TRAP seems most useful in differentiating lymphocytic malignancies from monocytic and histiocytic malignancies and from benign lymphocytoses when the cells of the peripheral blood and marrow may have similar morphologic features with routine staining.
在一名具有急性T细胞淋巴细胞白血病临床特征的患者的脑脊液（CSF）细胞复发期间，已证实存在抗酒石酸酸性磷酸酶（TRAP），这表明这种同工酶可能是某些类型淋巴细胞恶性转化的标志物。由于正常淋巴细胞似乎具有对酒石酸敏感的酸性磷酸酶，TRAP的存在可能有助于确立淋巴细胞恶性肿瘤的诊断。TRAP的存在不再被认为是毛细胞白血病的特异性指标，因为在患有急性淋巴细胞白血病的儿童的恶性母细胞中也发现了这种同工酶。TRAP的存在似乎并非恶性淋巴细胞的T或B细胞系所特有，因为在具有这两种细胞标志物类型的细胞中均有描述。当外周血和骨髓细胞经常规染色可能具有相似形态特征时，TRAP的存在在区分淋巴细胞恶性肿瘤与单核细胞和组织细胞恶性肿瘤以及良性淋巴细胞增多症方面似乎最为有用。
