某些催产素类似物对大鼠利钠作用的影响。
Effect of some oxytocin analogues on natriuresis in rats.
作者信息
Hrbas P, Barth T, Skopková J, Lebl M, Jost K
出版信息
Endocrinol Exp. 1980;14(2):151-7.
PMID:6967012
Abstract
Non-anaesthetized rats were used for studying the relationship between the amount of sodium excreted and structural modifications of oxytocin molecule. Any change performed in position 4 (i.e. the glutamine residue) resulted in a decrease of natriuretic activity as compared to that of oxytocin. The analogues with modifications in the amino-terminal part of the molecule (e.g. substitution of the amino group in position 1 by hydrogen, or of the disulfide bond by a thioether group) resulted in a higher natriuretic effect than oxytocin.
摘要
使用未麻醉的大鼠来研究钠排泄量与催产素分子结构修饰之间的关系。在第4位（即谷氨酰胺残基）进行的任何改变都会导致与催产素相比利钠活性降低。分子氨基末端部分有修饰的类似物（例如，第1位的氨基被氢取代，或二硫键被硫醚基团取代）产生了比利尿剂更高的利钠作用。
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