Frelinger J A, Frelinger J G
J Invest Dermatol. 1980 Jul;75(1):68-70. doi: 10.1111/1523-1747.ep12521247.
Using radiation bone marrow chimeras, we have shown that Ia molecules purified from epidermal cell preparations of the mouse reflect the Ia phenotype of the bone marrow donor. This result strongly suggests that Ia molecules are synthesized by a bone-marrow-derived cell in the epidermis. Furthermore, results of peptide map analysis of immunoprecipitated biosynthetically labeled Ia suggest that the Ia molecules found in skin are identical to those found on B lymphocytes. These results support biochemical as well as serologic identity.
通过使用辐射骨髓嵌合体，我们已经表明，从小鼠表皮细胞制剂中纯化的Ia分子反映了骨髓供体的Ia表型。这一结果有力地表明，Ia分子是由表皮中骨髓来源的细胞合成的。此外，对免疫沉淀的生物合成标记的Ia进行肽图谱分析的结果表明，皮肤中发现的Ia分子与B淋巴细胞上发现的Ia分子相同。这些结果支持了生化以及血清学上的一致性。
