Tsukunov S G, Gal'dinov G V
Fiziol Zh SSSR Im I M Sechenova. 1980 May;66(5):650-7.
Penicillin administration elicited epileptiform responses whereas micropolarization (MCP) affected the epileptogenic foci in cats with indwelled electrodes and chemotrodes. Three types of experimental epilepsy models were obtained: focal petit mal seizures, adversive, and grand mal seizures. The MCP of amygdala and caudate nucleus completely suppressed all three types of seizures whereas MCP of hippocampus enhanced the pathology. Two mechanisms of seizure suppression seem to exist: the inhibitory and the activating ones.
青霉素给药引发癫痫样反应,而微极化(MCP)对植入电极和化学电极的猫的致痫灶有影响。获得了三种实验性癫痫模型:局灶性小发作、旋转性发作和大发作。杏仁核和尾状核的微极化完全抑制了所有三种类型的发作,而海马体的微极化则加重了病理变化。似乎存在两种抑制发作的机制:抑制性机制和激活机制。