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[通过微极化脑结构抑制癫痫样活动]

[Suppression of epileptiform activity by micropolarizing brain structures].

作者信息

Tsukunov S G, Gal'dinov G V

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1980 May;66(5):650-7.

PMID:6967422
Abstract

Penicillin administration elicited epileptiform responses whereas micropolarization (MCP) affected the epileptogenic foci in cats with indwelled electrodes and chemotrodes. Three types of experimental epilepsy models were obtained: focal petit mal seizures, adversive, and grand mal seizures. The MCP of amygdala and caudate nucleus completely suppressed all three types of seizures whereas MCP of hippocampus enhanced the pathology. Two mechanisms of seizure suppression seem to exist: the inhibitory and the activating ones.

摘要

青霉素给药引发癫痫样反应,而微极化(MCP)对植入电极和化学电极的猫的致痫灶有影响。获得了三种实验性癫痫模型:局灶性小发作、旋转性发作和大发作。杏仁核和尾状核的微极化完全抑制了所有三种类型的发作,而海马体的微极化则加重了病理变化。似乎存在两种抑制发作的机制:抑制性机制和激活机制。

相似文献

1
[Suppression of epileptiform activity by micropolarizing brain structures].[通过微极化脑结构抑制癫痫样活动]
Fiziol Zh SSSR Im I M Sechenova. 1980 May;66(5):650-7.
2
[Effect of micropolarization of focal and extrafocal brain structures on experimental epilepsy].[局灶性和局灶外脑结构的微极化对实验性癫痫的影响]
Biull Eksp Biol Med. 1977 Jun;83(6):646-9.
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[The dual role of the caudate nucleus in regulating seizures].[尾状核在调节癫痫发作中的双重作用]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1975;75(3):444-50.
4
Experimental petit mal.
Trans Am Neurol Assoc. 1967;92:57-61.
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Neurophysiological mechanisms involved in grand mal seizures induced by Metrazol and Megimide.
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Neirofiziologiia. 1974 Nov-Dec;6(6):577-84.
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Differential epileptogenic action of penicillin on cortical and subcortical brain structures.
Electroencephalogr Clin Neurophysiol. 1967 Nov;23(5):491.
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[Clinical neurophysiology of epilepsy (according to findings from stereoelectroencephalographic studies)].[癫痫的临床神经生理学(基于立体脑电图研究结果)]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(9):1281-7.
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Low-frequency stimulation of the hippocampal CA3 subfield is anti-epileptogenic and anti-ictogenic in rat amygdaloid kindling model of epilepsy.在大鼠杏仁核点燃癫痫模型中,海马CA3亚区的低频刺激具有抗癫痫发生和抗发作作用。
Neurosci Lett. 2009 May 8;455(1):51-5. doi: 10.1016/j.neulet.2009.03.041. Epub 2009 Mar 17.
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[Phenomena of interaction between experimental bilateral amygdaloid epileptic foci in the cat].
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