D'Amore M, Quarto S, Terlizzi N, Martiradonna A, Carrozzo M
Minerva Med. 1980 Jul 31;71(29):2045-51.
Serum proline iminopeptidase and (where possible) urinary hydroxyproline were determined in 214 subjects: normal subjects, subjects with chronic kidney disease, subjects with chronic liver disease, subjects with osteitis deformans, subjects with rheumatoid arthritis, and subjects with osteoporosis. The values of the two parameters fully corresponded. It is suggested, therefore, that proline iminopeptidase can be determined instead of hydroxyproline in cases where a primarily destructive bone disease in present.
对214名受试者测定了血清脯氨酸亚氨基肽酶以及（如有可能）尿羟脯氨酸，这些受试者包括：正常受试者、慢性肾病患者、慢性肝病患者、变形性骨炎患者、类风湿关节炎患者以及骨质疏松症患者。这两个参数的值完全相符。因此，有人提出，在存在原发性破坏性骨病的情况下，可以测定脯氨酸亚氨基肽酶来替代羟脯氨酸。
