Iudel'son Ia B
Zh Nevropatol Psikhiatr Im S S Korsakova. 1980;80(4):526-30.
The results of a clinical and experimental study of the pathogenesis of secondary contractures of mimical muscles are presented. By means of clinico-electrophysiological studies 115 patients with postneuritic contractures are studied. A clinico-statistical analysis of 723 patients with facial nerve neuritis was conducted. For the first time it was possible to model the disease in 112 rabbits with an eventual complex study of the morphological basis and pathophysiological mechanisms of experimental contractures on all stages of its formation. As a result, some ways of accomplishing pathological reflectory influences on the affected nervous-muscular apparatus are defined on the part of the segmentary and suprasegementary structures of the brain stem. It was demonstrated that the direct reason of a disturbed functional state of these structures was an afferent desintegration, due to a crude lesion of the facial nerve and subsequently, it wrong regeneration with a change of the usual scheme of nervous-muscular relations. On the basis of obtained results a pathogenetic therapy of secondary contractures of mimical muscles with Tegretol was proposed and tried clinically.
本文介绍了关于表情肌继发性挛缩发病机制的临床与实验研究结果。通过临床电生理研究，对115例神经炎后挛缩患者进行了研究。对723例面神经神经炎患者进行了临床统计分析。首次在112只家兔身上模拟了该疾病，并对实验性挛缩形成各阶段的形态学基础和病理生理机制进行了全面研究。结果表明，脑干的节段性和超节段性结构对受影响的神经肌肉装置施加了一些实现病理反射性影响的途径。结果表明，这些结构功能状态紊乱的直接原因是传入性解体，这是由于面神经的严重损伤，随后是错误的再生，导致神经肌肉关系的正常模式发生改变。基于所得结果，提出并在临床上试用了用卡马西平治疗表情肌继发性挛缩的病因疗法。
