[Effect of antiserum against isologous aggregated immunoglobulins on synthesis of nonspecific immunoglobulins in mice immunized with sheep erythrocytes].

Injection of antiserum against isologous aggregated immunoglobulins into mice immunized with sheep red blood cells (5X10(7)) suppressed by 20% on the average the synthesis of nonspecific immunoglobulins. Concurrently the antiserum caused a 70% decrease in the amount of rosette-forming cells, but did not affect the proliferation of anti-body-forming cells and hemagglutinin production. The data obtained warrant an assumption that the part of B lymphocytes bearing aggregated antibodies are responsible for the synthesis of nonspecific immunoglobulins.