黏液溶解剂对犬气管黏液流变学及转运特性的影响。

The effect of mucolytic agents on the rheologic and transport properties of canine tracheal mucus.

作者信息

Martin R, Litt M, Marriott C

出版信息

Am Rev Respir Dis. 1980 Mar;121(3):495-500. doi: 10.1164/arrd.1980.121.3.495.

DOI:10.1164/arrd.1980.121.3.495

Abstract

The effect of several sulfhydryl and other agents on the rheologic and mucociliary transport properties of a model secretion, reconstituted canine tracheal mucus, was investigated. The mucus was obtained via the canine tracheal pouch. Rheologic properties were determined by mirorheometry, and the ciliary transport rate was determined using the frog palate technique. It was found that N-acetyl cysteine decreased the elastic modulus, leading to improved mucociliary transport at concentrations such that the mucin did not precipitate. S-carboxymethyl cysteine had no effect on either mucus properties or mucociliary transport rate, and its reported effectiveness in vivo must be due to some mechanism other than solubilization of mucin. Similar results were found with other blocked sulfhydryl compounds. Urea and potassium iodide to decrease mucus elasticity, but are harmful to cilia at the concentrations needed.

摘要

研究了几种巯基及其他试剂对一种模型分泌物——重组犬气管黏液的流变学和黏液纤毛转运特性的影响。黏液通过犬气管囊获取。流变学特性通过镜像流变测定法确定，纤毛转运速率使用蛙腭技术测定。结果发现，N-乙酰半胱氨酸降低了弹性模量，在黏蛋白不沉淀的浓度下改善了黏液纤毛转运。S-羧甲基半胱氨酸对黏液特性或黏液纤毛转运速率均无影响，其在体内的报道有效性必定归因于除溶解黏蛋白之外的某种机制。其他封闭巯基化合物也得到了类似结果。尿素和碘化钾可降低黏液弹性，但在所需浓度下对纤毛有害。