骨髓细胞、胸腺细胞和破骨细胞对氢化可的松的反应。
The response of bone marrow cells, thymocytes and osteoclasts to hydrocortisone.
作者信息
Johnell O, Hulth A
出版信息
Br J Exp Pathol. 1980 Aug;61(4):411-4.
Abstract
Hydrocortisone injections in young rats caused an increase in the proliferative response of bone marrow cells but a disintegration of thymus gland, the cells of which probably disappeared from thymus. Earlier investigations have shown that different kinds of trauma and antigen result in an increase in the mitotic rate of bone marrow and thymus cells and at the same time an increase in the number of osteoclasts. After steroids, however, no increase of osteoclasts occurred, probably because monocytes which develop into osteoclasts and macrophages are inhibited by hydrocortisone. The effect on serum calcium was minimal.
摘要
给幼鼠注射氢化可的松会导致骨髓细胞增殖反应增强，但胸腺会解体，胸腺细胞可能会从胸腺中消失。早期研究表明，不同类型的创伤和抗原会导致骨髓和胸腺细胞的有丝分裂率增加，同时破骨细胞数量也会增加。然而，使用类固醇后，破骨细胞没有增加，这可能是因为发育成破骨细胞和巨噬细胞的单核细胞受到氢化可的松的抑制。对血清钙的影响很小。
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