Vanderwolf C H, Robinson T E, Pappas B A
Brain Res. 1980 Nov 24;202(1):65-77.
A large dose of reserpine abolishes an atropine-resistant form of neocortical low voltage fast activity (LVFA) which normally accompanies certain patterns of motor activity in rats. An attempt was made to reverse this effect by replacement of specific monoamines or by injection of suitable agonists in rats pretreated with reserpine (10 mg/kg). The following compounds, alone or in various combinations, failed to restore atropine-resistant LVFA in reserpinized rats even though spontaneous motor activity was restored in many cases: L-DOPA (150-300 mg/kg) after pretreatment with an inhibitor of peripheral L-aromatic amino acid decarboxylase; 5-hydroxytryptophan (100-200 mg/kg); D-amphetamine (1-2 mg/kg); apomorphine (0.25-2.5 mg/kg); lysergic acid diethylamide (100-300 microgram/kg); and clonidine (0.5-1.0 mg/kg). In contrast beta-phenylethylamine was quite effective in restoring atropine-resistant LVFA and its effects were not diminished by pretreatment with alpha-methyl-p-tyrosine (400 mg/kg), chlorpromazine (15 mg/kg). It is suggested that a trace amine plays an essential role in the production of atropine-resistant LVFA independent of catecholamines.
大剂量利血平可消除一种对阿托品有抗性的新皮质低电压快速活动（LVFA），这种活动通常伴随大鼠特定的运动活动模式。研究人员尝试通过补充特定单胺或给预先用利血平（10毫克/千克）处理过的大鼠注射合适的激动剂来逆转这种效应。以下化合物单独或组合使用，即使在许多情况下恢复了自发运动活动，也未能在利血平化的大鼠中恢复对阿托品有抗性的LVFA：用外周L-芳香族氨基酸脱羧酶抑制剂预处理后的L-多巴（150 - 300毫克/千克）；5-羟色氨酸（100 - 200毫克/千克）；D-苯丙胺（1 - 2毫克/千克）；阿扑吗啡（0.25 - 2.5毫克/千克）；麦角酸二乙酰胺（100 - 微克/千克）；以及可乐定（0.5 - 1.0毫克/千克）。相比之下，β-苯乙胺在恢复对阿托品有抗性的LVFA方面相当有效，并且其效果不会因用α-甲基-p-酪氨酸（400毫克/千克）、氯丙嗪（15毫克/千克）预处理而减弱。研究表明，一种痕量胺在产生对阿托品有抗性的LVFA中起着独立于儿茶酚胺的关键作用。
