Matuliavichius V A, Coculescu M
Probl Endokrinol (Mosk). 1980 Sep-Oct;26(5):42-5.
The hydroosmotic activity of the cerebrospinal fluid in 38 persons of different ages and in 2 fetuses was investigated. In the fetal cerebrospinal fluid the hydroosmotic activity was undetectable. The highest hydroosmotic activity was observed in the cerebrospinal fluid of children aged 0 to 3 years (24.320 +/- 3530 microhydroosmotic units (mHOU/ml). The activity significantly decreased in the cerebrospinal fluid of children 7 to 10 years of age (13.184 +/- 2112 mHOU/ml, p < 0.01). The above activity was detected in 40% of the adult patients with different diseases and in all the cases of idiopathic diabetes insipidus. The hydroosmotic activity of both children and adults was sensitive to trypsin digestion. The data obtained suggest the presence of a basic peptide, probably arginine-vasotocin, in the cerebrospinal fluid studied. If this hypothesis is right, vasotocin occurres in the cerebrospinal fluid only after birth and decreases with age, with the exception of some cases of pathology.
对38名不同年龄的人和2名胎儿的脑脊液的渗透活性进行了研究。在胎儿脑脊液中未检测到渗透活性。在0至3岁儿童的脑脊液中观察到最高的渗透活性（24.320±3530微渗透单位（mHOU/ml））。7至10岁儿童脑脊液中的活性显著降低（13.184±2112 mHOU/ml，p<0.01）。在40%患有不同疾病的成年患者以及所有特发性尿崩症病例中检测到上述活性。儿童和成人的渗透活性对胰蛋白酶消化敏感。所获得的数据表明，在所研究的脑脊液中存在一种碱性肽，可能是精氨酸加压催产素。如果这一假设正确，加压催产素仅在出生后出现在脑脊液中，并随年龄增长而降低，但某些病理情况除外。
