Rea T H, Bevans L, Taylor C R
Int J Lepr Other Mycobact Dis. 1980 Sep;48(3):285-90.
The histopathology of the spleen from a young man with diffuse non-nodular lepromatous leprosy is reported. As judged by this case, other case reports, and necropsy series, involvement of the spleen in lepromatous leprosy is characterized by aggregations of large vacuolated histiocytes, containing individual bacilli and globi, in both the red and white pulp. In the white pulp the histiocytes localize about the arterioles. Findings in the present case, which may represent a comparatively early change, include numerous, small germinal centers containing nonaggregated large, vacuolated histiocytes with intracellular bacilli.
报告了一名患有弥漫性非结节性瘤型麻风的年轻男子脾脏的组织病理学情况。根据该病例、其他病例报告以及尸检系列判断，瘤型麻风患者的脾脏受累表现为红髓和白髓中均有大量含单个杆菌和麻风球的空泡化组织细胞聚集。在白髓中，组织细胞围绕小动脉分布。本病例中的发现可能代表相对早期的变化，包括众多含有未聚集的、带有细胞内杆菌的大空泡化组织细胞的小生发中心。
