Von Hahn H P, Honegger C G, Pletscher A
Neurosci Lett. 1980 Dec;20(3):319-22. doi: 10.1016/0304-3940(80)90167-6.
Blood platelets and brain membranes of SIV and Lewis rats both exhibited two saturable binding sites for 5-hydroxytryptamine (5-HT) in the concentration range 1-100 nM. The Kd values for the high-affinity sites were 4-6 nM and for the low-affinity sites 20-40 nM in both tissues of both rat strains. Blood platelets had 100-200 times more binding sites per mg protein (Bmax) than brain membranes. Thus, 5-HT receptors of platelets may be used as models for those of cerebral 5-HT-neurons.
在1-100 nM的浓度范围内，SIV大鼠和Lewis大鼠的血小板及脑膜均显示出5-羟色胺（5-HT）的两个可饱和结合位点。两种大鼠品系的两种组织中，高亲和力位点的Kd值为4-6 nM，低亲和力位点的Kd值为20-40 nM。每毫克蛋白质（Bmax），血小板的结合位点比脑膜多100-200倍。因此，血小板的5-HT受体可用作大脑5-HT神经元受体的模型。
