用99mTc标记的热处理红细胞检测胃肠道失血

Detection of gastrointestinal blood loss with 99mTc-labeled, heat-treated red blood cells.

作者信息

Som P, Oster Z H, Atkins H L, Goldman A G, Sacker D F, Harold W H, Fairchild R G, Richards P, Brill A B

出版信息

Radiology. 1981 Jan;138(1):207-9. doi: 10.1148/radiology.138.1.6969900.

DOI:10.1148/radiology.138.1.6969900

Abstract

Studies in dogs showed that heat-treated 99mTc-labeled red blood cells (HT/RBC) afford a highly sensitive means of detecting gastrointestinal bleeding as low as 0.12 ml/min., which could not be seen with unheated 99mTc-RBC, 99mTc-sulfur colloid, or 99mTc-DTPA. In addition, as the right upper quadrant and epigastrium remained free of activity, only one fifth to one tenth of the dose of 99mTc was needed. The safety of HT/RBC in humans has been documented, and the experiments in dogs suggest that it may have advantages over other agents in detecting gastrointestinal bleeding.

摘要

对狗的研究表明，经热处理的99mTc标记红细胞（HT/RBC）提供了一种高度灵敏的方法，可检测低至0.12毫升/分钟的胃肠道出血，而未加热的99mTc-RBC、99mTc-硫胶体或99mTc-DTPA则无法检测到这种出血。此外，由于右上腹和上腹部没有放射性，仅需要五分之一至十分之一剂量的99mTc。HT/RBC在人体中的安全性已有文献记载，对狗的实验表明，在检测胃肠道出血方面，它可能比其他药物更具优势。