腔内胃泌素会刺激胃酸分泌吗？

Does luminal gastrin stimulate gastric acid secretion?

作者信息

Ayalon A, Yazigi R, Devitt P, Rayford P L, Thompson J C

出版信息

Am J Surg. 1981 Jan;141(1):94-7. doi: 10.1016/0002-9610(81)90019-2.

Abstract

The effects of pentagastrin on acid secretion, short circuit current, electrical conductance and potential difference were determined in isolated bullfrog fundic mucosa. Biologically active luminal pentagastrin had no effect on gastric mucosa, even at a concentration 100 times higher than that necessary for stimulation of the mucosa from the serosal side. It is concluded that luminal gastrin does not appear to have a physiologic role in gastric secretory processes.

摘要

在离体牛蛙胃底黏膜中测定了五肽胃泌素对胃酸分泌、短路电流、电导和电位差的影响。具有生物活性的腔内五肽胃泌素对胃黏膜没有影响，即使其浓度比从浆膜侧刺激黏膜所需的浓度高100倍。得出的结论是，腔内胃泌素在胃分泌过程中似乎没有生理作用。