Cryptococcosis with multiple squamous cell tumors associated with a T-cell defect.

A 54-year-old male with multiple squamous cell tumors was shown to have capsule deficient cryptococcosis confined to bone. Further investigations revealed a severe defect of cell-mediated immunity and the presence of serum antinuclear factor. An underlying T-cell defect might explain the unusual cryptococcal infection and the extremely aggressive behavior of the skin tumors.