Lee J C, Ihle J N
Nature. 1981 Jan 29;289(5796):407-9. doi: 10.1038/289407a0.
C-type viruses are known to be aetiologically related to naturally occurring leukaemia in a variety of species, although the mechanisms of transformation are largely unknown. The long latency periods, requirement for an acute viraemia and monoclonality of the tumours distinguish leukaemogenesis from neoplasias induced by the acute transforming viruses and suggest an indirect mechanism. Consistent with this is the lack of in vitro transforming activity of replication-competent leukaemogenic viruses. We have shown previously that the presence of T cells which proliferate in vitro in response to viral antigens is uniquely associated with the conditions leading to leukaemia. Based on these observations we have hypothesized that chronic immune stimulation is required for leukaemogenesis. We now demonstrate that CBA/N mice, when inoculated as newborns with Moloney leukaemia virus (MoLV), develop an acute viraemia but do not develop leukaemia or have detectable T-cell responses against the virus. This supports the hypothesis that chronic immune stimulation is essential for leukaemogenesis.
已知C型病毒在病因学上与多种物种的自然发生的白血病有关，尽管转化机制在很大程度上尚不清楚。肿瘤的长潜伏期、急性病毒血症的需求和单克隆性将白血病发生与急性转化病毒诱导的肿瘤形成区分开来，并提示一种间接机制。与此一致的是，具有复制能力的致白血病病毒缺乏体外转化活性。我们之前已经表明，体外对病毒抗原增殖的T细胞的存在与导致白血病的条件独特相关。基于这些观察结果，我们假设白血病发生需要慢性免疫刺激。我们现在证明，CBA/N小鼠在新生时接种莫洛尼白血病病毒（MoLV）后会出现急性病毒血症，但不会发生白血病，也没有可检测到的针对该病毒的T细胞反应。这支持了慢性免疫刺激对白血病发生至关重要的假设。
