von Smitten K, Stenman S, Scheinin T M
Acta Chir Scand. 1980;146(4):253-60.
The supradiaphragmatic inferior vena cava was syngeneically transplanted into the infrarenal part of the abdominal aorta in rats of inbred strains. The initial histologic changes coincided with the changes usually seen in wound healing during the inflammatory phase and the phase of fibroplasia. Later the reparative process occurred predominantly in the luminal part of the vein wall, and was usually seen as intimal hyperplasia. In some grafts this process caused a narrowing of the lumen. In this particular experimental model the thickening of the intimal layer was mainly due to organization of fibrin layering thrombus. This was shown by detection of lamellar fibrin deposits and a high concentration of fibronectin in this layer. A large amount of fibronectin was detected in and around the proliferating fibroblasts and in thrombi. This explains the high concentration of fibronectin in the proliferating intimal layer of the graft.
将同基因的膈上腔静脉移植到近交系大鼠的肾下腹主动脉中。最初的组织学变化与炎症期和纤维增生期伤口愈合时通常所见的变化一致。后来修复过程主要发生在静脉壁的管腔部分，通常表现为内膜增生。在一些移植物中，这个过程导致管腔狭窄。在这个特定的实验模型中，内膜层增厚主要是由于纤维蛋白分层血栓的机化。这通过检测该层中的片状纤维蛋白沉积物和高浓度的纤连蛋白得以证实。在增殖的成纤维细胞内和周围以及血栓中检测到大量纤连蛋白。这解释了移植物增殖内膜层中纤连蛋白的高浓度。
