Fregly M J, Connor T M, Kikta D C, Threatte R M
Brain Res Bull. 1980 Nov-Dec;5(6):719-24. doi: 10.1016/0361-9230(80)90211-7.
The precursor of serotonin, l-hydroxytryptophan (5HTP), is a potent dipsogen in the rat. Peripheral administration of increasing doses of this compound increased water intake in a dose-dependent fashion. Peripheral administration of other analogs of tryptophan, including d-tryptophan, l-tryptophan and acetyltryptophan, failed to affect water intake at a dose at which 5HTP induced maximal drinking (25 mg/kg, SC). The dipsogenic effect of melatonin, one of the metabolites of serotonin, was also tested. At any of 6 different doses (0.5 to 50 mg/kg, SC), melatonin failed to affect water intake in the rat. The mechanism by which 5HTP induces drinking is not known with certainty but could involve its conversion to serotonin, a known dipsogenic agent.
血清素的前体，L-羟色氨酸（5HTP），是大鼠体内一种有效的致渴剂。外周给予递增剂量的该化合物会以剂量依赖的方式增加水的摄入量。外周给予色氨酸的其他类似物，包括D-色氨酸、L-色氨酸和乙酰色氨酸，在5HTP诱导最大饮水量时的剂量（25mg/kg，皮下注射）下未能影响水的摄入量。还测试了血清素的代谢产物之一褪黑素的致渴作用。在6种不同剂量（0.5至50mg/kg，皮下注射）的任何一种剂量下，褪黑素均未影响大鼠的水摄入量。5HTP诱导饮水的确切机制尚不清楚，但可能涉及其转化为血清素，一种已知的致渴剂。
