Moore G P, Panaretto B A, Robertson D
J Endocrinol. 1981 Feb;88(2):293-9. doi: 10.1677/joe.0.0880293.
The growth of the first hair coat in male mice was studied during administration of epidermal growth factor (EGF). Injections of 1 or 4 micrograms EGF/g body weight for 14 consecutive days from birth resulted in the development of curved overhairs (monotrichs), caused a retardation in rate of growth in length of hair and a reduction in hair diameter and length of follicle bulb. Growth rate partially recovered after cessation of EGF treatment. However, some of the effects produced by injections of EGF during the formation of the first coat were detected in the second and third generations of hair. Since EGF also retarded rate of body growth, we compared the effect of EGF on hair growth with that of restricting food intake in neonatal mice during the development of the first coat. Hair growth was slowed in underfed animals but the effects were less marked than those found in EGF-treated mice of similar body weights.
在给予表皮生长因子（EGF）期间，对雄性小鼠首次毛发覆盖的生长情况进行了研究。从出生起连续14天每天注射1或4微克EGF/克体重，导致弯曲的终毛（单毛）发育，使毛发生长长度的速率减慢，毛发直径和毛囊球长度减小。停止EGF治疗后，生长速率部分恢复。然而，在第一代毛发形成过程中注射EGF所产生的一些影响在第二代和第三代毛发中也被检测到。由于EGF也会减缓身体生长速率，我们将EGF对毛发生长的影响与新生小鼠在首次毛发覆盖发育期间限制食物摄入量的影响进行了比较。食物摄入不足的动物毛发生长减慢，但影响程度不如体重相似的EGF处理小鼠明显。
