疱疹样皮炎中的人类白细胞抗原-DR3

HLA-DR3 in dermatitis herpetiformis.

作者信息

Pehamberger H, Holubar K, Mayr W R

出版信息

Br J Dermatol. 1981 Mar;104(3):321-4. doi: 10.1111/j.1365-2133.1981.tb00956.x.

DOI:10.1111/j.1365-2133.1981.tb00956.x

Abstract

Twenty-one patients with dermatitis herpetiformis were typed for HLA-ABC and -DR determinants. The incidence of HLA-AI, -B8 and -DR3 antigens was found to be significantly higher (P: = 10(-3), less than 10(-6) and less than 10(-6), respectively) among patients with dermatitis herpetiformis than among the normal population. HLA-DR3 was found in 85.7% of patients, HLA-B8 in 66.7% and HLA-AI in 61.9% only. These results indicate that HLA-DR3 is the antigen primarily associated in dermatitis herpetiformis and the latter antigens (HLA-AI and -B8) are present in increased incidence, probably due to the known linkage disequilibrium of these antigens with HLA-DR3.

摘要

对21例疱疹样皮炎患者进行了HLA - ABC和 - DR抗原分型。发现疱疹样皮炎患者中HLA - A1、 - B8和 - DR3抗原的发生率显著高于正常人群（P值分别为10⁻³、小于10⁻⁶和小于10⁻⁶）。仅在85.7%的患者中发现了HLA - DR3，66.7%的患者中发现了HLA - B8，61.9%的患者中发现了HLA - A1。这些结果表明，HLA - DR3是与疱疹样皮炎主要相关的抗原，而后两种抗原（HLA - A1和 - B8）发生率增加，可能是由于这些抗原与HLA - DR3已知的连锁不平衡所致。