Dominioni L, Dionigi R, Prati U, Cividini F, Cincera M, Pavesi L, Della Cuna G R
Minerva Med. 1981 Mar 31;72(12):733-40.
Cellular immunity has been studied in 92 patients with solid tumors undergoing surgery, in order to evaluate immunocompetence at the time of diagnosis and to assess the prognostic value of parameters of cellular immunity. The results show that total lymphocyte counts, T-lymphocyte counts and lymphocyte blastogenic responses are moderately depressed at diagnosis in the cancer patients as compared to age matched controls. These parameters of cell mediated immunity "in vitro" seem to be of limited prognostic value, since no correlation was found with the clinical course during the first 6 postoperative months. Depression of delayed hypersensitivity response to cutaneous antigens appeared to be an index of poor prognosis.
对92例接受手术的实体瘤患者的细胞免疫进行了研究,以评估诊断时的免疫能力,并评估细胞免疫参数的预后价值。结果显示,与年龄匹配的对照组相比,癌症患者在诊断时总淋巴细胞计数、T淋巴细胞计数和淋巴细胞增殖反应中度降低。这些“体外”细胞介导免疫参数的预后价值似乎有限,因为在前6个月的术后临床过程中未发现相关性。对皮肤抗原的迟发型超敏反应降低似乎是预后不良的一个指标。