Harris J, Stewart T, Sengar D P, Hyslop D
Can Med Assoc J. 1975 Apr 19;112(8):948-52.
The absolute number of T- and B-lymphocytes in the peripheral blood was measured in 22 patients with disseminated nonlymphoid solid malignant tumours. Patients with normal absolute lymphocyte counts had normal absolute numbers of T- and B-lymphocytes; patients with low counts had low numbers. The percentage of T- and B-lymphocytes was similar, in both groups of patients, to that of healthy control subjects. Patients with a normal absolute lymphocyte count had better in vitro lymphocyte responses to mitogenic agents than did patients with low absolute lymphocyte counts. Improvement of depressed in vitro lymphocyte responses to normal on culture of cells in AB plasma was most likely in patients with normal absolute lymphocyte counts. The absolute lymphocyte count by itself, then, provides useful information about the immune status of patients with solid malignant tumours.
对22例播散性非淋巴样实体恶性肿瘤患者外周血中的T淋巴细胞和B淋巴细胞的绝对数量进行了测定。外周血淋巴细胞绝对计数正常的患者，其T淋巴细胞和B淋巴细胞的绝对数量也正常；计数低的患者，其T淋巴细胞和B淋巴细胞数量也低。两组患者中T淋巴细胞和B淋巴细胞的百分比与健康对照者相似。外周血淋巴细胞绝对计数正常的患者，其体外淋巴细胞对促有丝分裂剂的反应比外周血淋巴细胞绝对计数低的患者更好。在外周血淋巴细胞绝对计数正常的患者中，将细胞培养于AB血浆中时，体外淋巴细胞反应从受抑制状态恢复至正常状态的可能性最大。因此，外周血淋巴细胞绝对计数本身就能为实体恶性肿瘤患者的免疫状态提供有用信息。
