Akasu T, Hirai K, Koketsu K
Brain Res. 1981 Apr 27;211(1):217-20. doi: 10.1016/0006-8993(81)90087-1.
Experimental evidences showing that 5-hydroxytryptamine (5-HT) is directly interacting with nicotinic acetylcholine (ACh) receptors and thereby depresses the sensitivity of these receptors to ACh, are presented by making use of bullfrog sympathetic ganglion cells and frog skeletal muscle endplates. It was suggested that 5-HT might decrease the affinity of ACh to nicotinic receptor sites, since the mode of 5-HT action was comparable to that of D-tubocurarine action.
利用牛蛙交感神经节细胞和青蛙骨骼肌终板，提供了实验证据表明5-羟色胺（5-HT）直接与烟碱型乙酰胆碱（ACh）受体相互作用，从而降低这些受体对ACh的敏感性。有人提出5-HT可能会降低ACh对烟碱型受体位点的亲和力，因为5-HT的作用方式与筒箭毒碱的作用方式相似。
