Belghiti D, Vernant J P, Hirbec G, Gubler M C, Andre C, Sobel A
Cancer. 1981 Apr 1;47(7):1878-82. doi: 10.1002/1097-0142(19810401)47:7<1878::aid-cncr2820470727>3.0.co;2-i.
Glomerulopathies associated with non-Hodgkin's malignant lymphomas have been observed rarely. Previous reports have never determined the cell type of the lymphoproliferative disorder. This report documents a case of nephrotic syndrome in a patient with T-cell derived non-Hodgkin's lymphoma. The neoplastic cell was studied in terms of cell-surface markers, cytochemical staining, and ultrastructural morphology. Nephrotic syndrome occurred shortly after the apparent onset of the lymphoma. The kidney biopsy specimen was examined by light, fluorescence, and electron microscopy. Histologic findings were consistent with the diagnosis of mild focal and segmental glomerulosclerosis. Such an association, reported here for the first time, may support the hypothesis of a pathogenetic link between acquired T-cell abnormalities and glomerular diseases with minimal histologic injury.
与非霍奇金恶性淋巴瘤相关的肾小球病很少见。既往报告从未确定过淋巴细胞增殖性疾病的细胞类型。本报告记录了1例T细胞来源的非霍奇金淋巴瘤患者发生肾病综合征的病例。对肿瘤细胞进行了细胞表面标志物、细胞化学染色及超微结构形态学研究。肾病综合征在淋巴瘤明显起病后不久发生。对肾活检标本进行了光镜、荧光及电镜检查。组织学表现符合轻度局灶节段性肾小球硬化的诊断。本文首次报道的这种关联可能支持获得性T细胞异常与组织学损伤轻微的肾小球疾病之间存在发病机制联系的假说。
