Capelli L, Chianese V, La Montagna G, Giordano M
Curr Med Res Opin. 1981;7(4):227-33. doi: 10.1185/03007998109114267.
Twenty-three patients with rheumatoid arthritis and 9 patients with other forms of rheumatic diseases were treated for 20 days with 420 mg glucametacin per day, given as three 140 mg capsules. The treatment produced anti-inflammatory effects which were rated as good in about half the cases, with improvement of the majority of the clinical parameters studied. There were mild digestive side-effects. One patient with gallstones developed biliary colic, but the relationship of this to glucametacin treatment was not clear. The results obtained in the 32 patients treated with 140 mg glucametacin capsules were very similar to those which the same authors had observed in a very extensive case series of patients with rheumatic diseases treated with the same daily dose, but given as 70 mg capsules. It is suggested that the new preparation, which halves the number of capsules taken each day, is to be preferred to the smaller dose capsules.
23名类风湿性关节炎患者和9名其他形式风湿性疾病患者接受了为期20天的治疗，每天服用420毫克葡甲胺，分三次服用，每次140毫克胶囊。治疗产生了抗炎效果，约一半病例的效果被评为良好，大多数研究的临床参数都有所改善。有轻微的消化系统副作用。一名胆结石患者出现胆绞痛，但这与葡甲胺治疗的关系尚不清楚。用140毫克葡甲胺胶囊治疗的32名患者所获得的结果与同一组作者在一个非常广泛的病例系列中观察到的结果非常相似，该病例系列中的风湿性疾病患者接受相同的日剂量治疗，但服用的是70毫克胶囊。建议新制剂每天服用的胶囊数量减半，比小剂量胶囊更可取。
