The intracellular mechanism of action of metoprine (DDMP). - Suppr | 超能文献

The intracellular mechanism of action of metoprine (DDMP).

作者信息

Browman G P, Calvert A H, Taylor G A, Hart L I, Harrap K R

出版信息

Eur J Cancer (1965). 1980 Dec;16(12):1547-54. doi: 10.1016/0014-2964(80)90027-4.

DOI:10.1016/0014-2964(80)90027-4

Abstract

摘要

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The intracellular mechanism of action of metoprine (DDMP).

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Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate.对2,4-二氨基-5-(3',4'-二氯苯基)-6-甲基嘧啶（DDMP）耐药且对甲氨蝶呤无交叉耐药性的L1210白血病细胞系进行的研究。

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An antifolate-induced lesion in newly synthesized DNA.

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Limited effectiveness of in vitro high-dose methotrexate and leucovorin to overcome resistance in L1210 leukemia cells with elevations of dihydrofolate reductase.体外高剂量甲氨蝶呤和亚叶酸钙克服二氢叶酸还原酶升高的L1210白血病细胞耐药性的效果有限。

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Comparative studies of methotrexate and metoprine: metabolic toxicity and cell killing.

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On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA.关于甲氨蝶呤对二氢叶酸还原酶的抑制作用与脱氧核苷掺入DNA之间的弱相关性。

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引用本文的文献

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Phase II clinical trial of DDMP (2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine) and folinic acid (CF) in solid tumors.DDMP（2,4-二氨基-5-（3',4'-二氯苯基）-6-甲基嘧啶）与亚叶酸（CF）联合用于实体瘤的II期临床试验。

Cancer Chemother Pharmacol. 1981;6(1):81-4. doi: 10.1007/BF00253014.

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Phase I clinical trial and pharmacology of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (metoprine) (DDMP) and folinic acid (CF).2,4-二氨基-5-（3'，4'-二氯苯基）-6-甲基嘧啶（美托普林）（DDMP）与亚叶酸（CF）的I期临床试验及药理学研究

Cancer Chemother Pharmacol. 1981;6(1):75-80. doi: 10.1007/BF00253013.

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Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines.亚叶酸在人淋巴细胞系中对多种抗叶酸剂的保护作用比较。

Cancer Chemother Pharmacol. 1985;15(2):111-4. doi: 10.1007/BF00257519.