Churg A, Warnock M L, Bensch K G
Am Rev Respir Dis. 1978 Aug;118(2):419-24. doi: 10.1164/arrd.1978.118.2.419.
A case of mesothelioma, apparently arising in the pericardium, is reported in a patient who, 15 years previously, had been treated for angina pectoris by dusting of the pericardial cavity with a mixture of fibrous dusts. At autopsy, transparent fibers and ferruginous bodies were present within the pericardium. Electron diffraction and microprobe analysis indicated that approximately two thirds of the fibers were tremolite and anthophyllite asbestos, and the remainder, fiber glass. Development of mesothelioma in laboratory animals has been reported after intrapleural deposition of asbestos and other fibers, but in humans, the link between exposure to asbestos and mesothelioma has always been based on epidemiologic data and the retrospective finding of asbestos in tissues. To our knowledge, this is the first example of a malignant mesothelioma in a human associated with direct mesothelial contact with fibrous dusts.
据报道，一名患者患间皮瘤，显然起源于心包，该患者15年前曾因心绞痛接受心包腔注入纤维性粉尘混合物的治疗。尸检时，心包内发现有透明纤维和含铁小体。电子衍射和微探针分析表明，约三分之二的纤维为透闪石和直闪石石棉，其余为玻璃纤维。实验动物在胸膜腔内注入石棉和其他纤维后已报道会发生间皮瘤，但在人类中，接触石棉与间皮瘤之间的联系一直基于流行病学数据以及在组织中回顾性发现石棉。据我们所知，这是人类中恶性间皮瘤与间皮直接接触纤维性粉尘相关的首个实例。
