1,25-二羟维生素D3与24,25-二羟维生素D3在肾性骨营养不良长期治疗中的比较
Comparison of 1,25(OH)2D3 and 24,25(OH)2D3 in the long-term treatment of renal osteodystrophy.
作者信息
Muirhead N, Catto G R, Edward N, Fraser R A, O'Riordan J L, Papapoulos S E, Adami S
出版信息
Proc Eur Dial Transplant Assoc. 1980;17:543-7.
24,25(OH)2D3 has been compared with 1,25(OH)2D3 in the treatment of renal osteodystrophy. Treatment with 24, 25(OH)2D3 2 micrograms/day for 5-7 months was accompanied by deterioration in clinical, biochemical, radiological and histological features of osteodystrophy with no increase in Ca absorption. In contrast, treatment with 1,25(OH)2D3 0.25--1 microgram/day for 6-15 months resulted in rapid improvement in clinical, biochemical, radiological and histological features and a return of Ca absorption to normal. It is concluded that in the dose used 24,25(OH)2D3 alone is not an effective treatment for renal osteodystrophy.
已对24,25(OH)₂D₃和1,25(OH)₂D₃治疗肾性骨营养不良的效果进行了比较。每天服用2微克24,25(OH)₂D₃，持续5 - 7个月，结果骨营养不良的临床、生化、放射学和组织学特征均恶化，且钙吸收未增加。相比之下，每天服用0.25 - 1微克1,25(OH)₂D₃，持续6 - 15个月，临床、生化、放射学和组织学特征迅速改善，钙吸收恢复正常。得出的结论是，就所使用的剂量而言，单独使用24,25(OH)₂D₃并非治疗肾性骨营养不良的有效方法。
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