Cowdery J S, Taurog J D, Steinberg A D
Scand J Immunol. 1980;12(6):499-502. doi: 10.1111/j.1365-3083.1980.tb00097.x.
We have used the CBA/N X-linked B-cell maturation defect (xid) as a probe to analyse the B-cell subset involved in spontaneous anti-DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti-DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non-overlapping B-cell subsets are responsible for the spontaneous production of anti-DNA in MRL/1 and NZB mice.
我们利用CBA/N X连锁B细胞成熟缺陷（xid）作为探针，分析参与MRL/1和NZB小鼠自发抗DNA产生的B细胞亚群。NZB后代中xid的存在显著抑制了抗DNA的产生，而在MRL/1后代中它并未抑制自发产生的抗DNA抗体。这些研究表明，在很大程度上不重叠的B细胞亚群负责MRL/1和NZB小鼠中抗DNA的自发产生。
