Sabbe L J, Claas F H, Haak H L, van Gemert G W, Jansen J, Zwaan F E, Tricot G, Niterink A, Langerak J, van Rood J J
Blut. 1981 Jun;42(6):331-5. doi: 10.1007/BF00996895.
Of the 14 patients with aplastic anaemia treated in our hospital with anti-thymocyte globulin (ATG), four were refractory to random platelets before therapy due to the presence of leucocyte antibodies. In contrast to the ten nonrefractory patients in whom no success was obtained, three of the four refractory patients showed haematological improvement after ATG. Additionally, two patients could be substituted again with random platelets. The other two hardly needed platelet-transfusions after ATG, and they were given HLA-compatible platelets. To determine the degree of immunosuppression, these four patients were tested for the presence of antibodies against leucocytes and two endemic viruses, i.e., mumps and rubella virus. Before ATG, all sera reacted with almost the whole leucocyte testpanel. After treatment, the leucocyte antibodies disappeared completely in three patients. In one patient there was no dramatic change. In all patients, however, the antibody-titre against the mumps and rubella viruses remained constant and there was only a slight decrease in total IgG content in the three "suppressed" patients. We conclude that it might be worthwhile to study systematically the selective immuno-suppressive effect of ATG.
在我院接受抗胸腺细胞球蛋白（ATG）治疗的14例再生障碍性贫血患者中，有4例在治疗前因存在白细胞抗体而对随机血小板无效。与10例未取得成功的非难治性患者不同，4例难治性患者中有3例在接受ATG治疗后血液学状况得到改善。此外，有2例患者可以再次改用随机血小板。另外2例在接受ATG治疗后几乎不需要血小板输注，他们接受了人类白细胞抗原（HLA）配型相合的血小板。为了确定免疫抑制程度，对这4例患者检测了抗白细胞抗体以及两种地方性病毒，即腮腺炎病毒和风疹病毒的抗体。在接受ATG治疗前，所有血清几乎与整个白细胞检测板发生反应。治疗后，3例患者的白细胞抗体完全消失。1例患者没有明显变化。然而，在所有患者中，针对腮腺炎病毒和风疹病毒的抗体滴度保持不变，3例“免疫抑制”患者的总免疫球蛋白G（IgG）含量仅略有下降。我们得出结论，系统研究ATG的选择性免疫抑制作用可能是值得的。
