用人正常细胞重建的免疫抑制小鼠体内人结肠肿瘤异种移植物的生长
Growth of human colorectal tumor xenografts in immunosuppressed mice reconstituted with normal cells.
作者信息
Kopper L, Van Hanh T, Hegedüs C, Lapis K
出版信息
Exp Cell Biol. 1981;49(3):141-7. doi: 10.1159/000163816.
The growth of human colorectal tumor xenograft lines was studied in immunosuppressed mice after reconstitution with sensitized and nonsensitized macrophages, thymocytes and splenocytes obtained from normal mice. Intravenously injected macrophages caused temporary inhibition of tumor growth. This effect needed intact cells and was independent from the presence of the spleen. The weight of spleen increased in normal mice sensitized with xenograft tumor, and the sensitized splenocytes injected into tumor-bearing immunosuppressed mice caused substantial tumor-growth delay.
在用从正常小鼠获得的致敏和未致敏巨噬细胞、胸腺细胞和脾细胞进行重建后，在免疫抑制小鼠中研究了人结肠直肠肿瘤异种移植系的生长情况。静脉注射巨噬细胞会导致肿瘤生长暂时受到抑制。这种效应需要完整的细胞，且与脾脏的存在无关。用异种移植肿瘤致敏的正常小鼠脾脏重量增加，将致敏脾细胞注射到荷瘤免疫抑制小鼠中会导致肿瘤生长显著延迟。
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