Cihak J, Ziegler H W, Kölsch E
Immunology. 1981 May;43(1):145-52.
Protective immunity towards a lethal dose of 10(4) living ADJ-PC-5 cells can be induced in 56% of BALB/c mice by treating them with 10(7) irradiated cells. This protection can be modulated by pretreatment of animals with lower numbers of irradiated tumour cells. Repeated injections of 10(1) cells before immunization and challenge with tumour cells lead to tumours in only 16% of the animals, whereas repeated injections of 10(5) cells shift the tumour incidence to 78%. The enhanced tumour incidence is paralleled by suppression of T-cell cytotoxicity which can be transferred by spleen cells into 100 r-irradiated BALB/c mice. The possible significance of induction of specific immunosuppression during the initial stages of tumour growth is discussed. It is stressed that this suppression becomes effective at a dose 10(3) times lower than that which could induce protective immunity.
用10⁷个经辐照的细胞处理BALB/c小鼠，可使56%的小鼠对10⁴个活的ADJ-PC-5细胞的致死剂量产生保护性免疫。这种保护作用可通过用较少数量的经辐照肿瘤细胞对动物进行预处理来调节。在免疫和用肿瘤细胞攻击之前，重复注射10¹个细胞，只有16%的动物会发生肿瘤，而重复注射10⁵个细胞会使肿瘤发生率升至78%。肿瘤发生率的增加与T细胞细胞毒性的抑制平行，这种抑制可通过脾细胞转移到100伦琴辐照的BALB/c小鼠体内。文中讨论了肿瘤生长初始阶段诱导特异性免疫抑制的可能意义。强调这种抑制在比诱导保护性免疫的剂量低10³倍时就开始起作用。
