Kragballe K, Zachariae H, Herlin T, Jensen J
Br J Dermatol. 1981 Jul;105(1):13-8. doi: 10.1111/j.1365-2133.1981.tb00877.x.
Six children with histiocytosis X, all in clinical remission, were investigated for antibody-dependent cytotoxicity mediated by monocytes and neutrophils. Monocytes demonstrated a reduced cytotoxicity and a normal Fc receptor activity. Judged by light microscopy the monocytes were normal. Preincubation with the patient's serum did not influence the cytotoxicity of normal monocytes. Neutrophils from patients with histiocytosis X showed a normal cytotoxic activity. We postulate a functional defect of the mononuclear phagocyte system in histiocytosis X.
对6例处于临床缓解期的组织细胞增多症X患儿进行了单核细胞和中性粒细胞介导的抗体依赖性细胞毒性研究。单核细胞表现出细胞毒性降低和Fc受体活性正常。通过光学显微镜判断，单核细胞正常。用患者血清预孵育不影响正常单核细胞的细胞毒性。组织细胞增多症X患者的中性粒细胞表现出正常的细胞毒性活性。我们推测组织细胞增多症X中单核吞噬细胞系统存在功能缺陷。
