Nell L J, Richie E R
Exp Hematol. 1981 Jul;9(6):611-8.
Eight spontaneous thymic lymphomas from AKR mice were characterized individually in vitro for cell surface receptors and mitogen reactivity. One of the thymic lymphomas, designated 105, displayed receptors for the Fc region of immunoglobulin and for complement on a portion of the Thy-1-positive lymphoid blasts. The other T cell lymphomas did not display either receptor, and none expressed cell surface immunoglobulin. This was in contrast to the distinct behavior of each lymphoma in culture in both spontaneous and mitogen-stimulated tritiated thymidine [3H]-dThd uptake. After 48 h of culture, spontaneous [3H]-dThd uptake of the individual lymphomas ranged from 137 +/- 27 cpm to 100,442 +/- 13,422 cpm. Four of the spontaneous lymphomas did not respond to T cell mitogens by increased [3H]-dThd uptake. One lymphoma responded to the T cell mitogen concanavalin A only, whereas two lymphomas were stimulated by both phytohemagglutinin and concanavalin A. None of the lymphomas were stimulated by the B cell mitogen, lipopolysaccharide.
对来自AKR小鼠的8例自发性胸腺淋巴瘤进行了体外细胞表面受体和丝裂原反应性的个体特征分析。其中一例胸腺淋巴瘤，编号为105，在部分Thy-1阳性淋巴母细胞上显示出免疫球蛋白Fc区受体和补体受体。其他T细胞淋巴瘤均未显示这两种受体，也没有表达细胞表面免疫球蛋白。这与各淋巴瘤在培养中对自发和丝裂原刺激的氚标记胸腺嘧啶核苷（[3H]-dThd）摄取的不同行为形成对比。培养48小时后，各淋巴瘤的自发[3H]-dThd摄取量在137±27 cpm至100,442±13,422 cpm之间。4例自发性淋巴瘤对T细胞丝裂原刺激的[3H]-dThd摄取量未增加。1例淋巴瘤仅对T细胞丝裂原刀豆球蛋白A有反应，而2例淋巴瘤对植物血凝素和刀豆球蛋白A均有反应。所有淋巴瘤均未被B细胞丝裂原脂多糖刺激。
