日本人群中B细胞同种抗原与青少年型糖尿病的关联。

Association of B cell alloantigen with juvenile onset diabetes mellitus in the Japanese.

作者信息

Moriuchi J, Katagiri M, Wakisaka A, Matsuura N, Maruyama N, Ikeda H, Aizawa M, Itakura K

出版信息

Hum Immunol. 1980 Dec;1(4):357-62. doi: 10.1016/0198-8859(80)90111-1.

Abstract

Sixty-four Japanese insulin dependent juvenile onset diabetes mellitus (JOD) were studied in relation to HLA-A, B, and DR. Significant deviations were observed. HLA-Bw54 was increased (PF = 49.2%, RR = 6.4) and HLA-B5 was decreased (PF = 7.9%, RR = 0.19). Using radioimmunoassay, two HLA-DR antigens were investigated. Hon 7 antigen, so-called MT3 (WIA4x7), which has linkage disequilibrium between HLA-BW54, is highly associated (PF = 96.9%, RR = 27.8) with JOD found in the Japanese.

摘要

对64例日本胰岛素依赖型青少年发病型糖尿病（JOD）患者进行了与HLA - A、B和DR相关的研究。观察到显著偏差。HLA - Bw54增加（PF = 49.2%，RR = 6.4），而HLA - B5减少（PF = 7.9%，RR = 0.19）。使用放射免疫分析法对两种HLA - DR抗原进行了研究。在日本人群中发现，所谓的MT3（WIA4x7）即Hon 7抗原，其与HLA - BW54之间存在连锁不平衡，与JOD高度相关（PF = 96.9%，RR = 27.8）。