甲氧苄啶/磺胺甲恶唑治疗卡氏肺孢子虫肺炎时直肠吸收不佳。
Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia.
作者信息
Dorr R T, Powell J R, Heick M, Barry D W
出版信息
Postgrad Med J. 1981 Feb;57(664):123-5. doi: 10.1136/pgmj.57.664.123.
A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was tested with trimethoprim/sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) or the suppository dose absorbed for TMP and SMX were 3.0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained.
一名患有霍奇金病和卡氏肺孢子虫肺炎的24岁女性接受了甲氧苄啶/磺胺甲恶唑（TMP/SMX）片剂治疗。由于担心因慢性呕吐可能导致药物吸收不完全而治疗失败，在口服给药第5天后通过直肠栓剂给予相同剂量的TMP/SMX。TMP和SMX的直肠吸收相对分数（直肠/口服）或栓剂剂量分别为3.0%和19.5%。当需要TMP/SMX治疗且口服途径不可行时，应获取研究用静脉制剂。
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