[类风湿性关节炎患儿的细胞免疫缺陷与趋化性缺陷]
[Cellular immunity deficiency and chemotaxis deficiency in children with rheumatoid arthritis].
作者信息
Calandi C, Fantacci C, Adami Lami Conti C, Redi Orienti M, De Martino M, Vierucci A
出版信息
Ann Sclavo. 1980 Sep-Oct;22(5):846-56.
PMID:6973957
Abstract
Some immunological parameters have been examined in eleven children with juvenile rheumatoid arthritis. A quantitative and functional defect in T lymphocytes has been observed associated with defective chemotaxis of neutrophils. High levels of circulating immune-complexes were detected in sera of 5 out 11 patients. 1 patient showed high levels of antinuclear antibodies and positivity for the rheumatoid factor. Immunological pathogenesis of juvenile rheumatoid arthritis is discussed.
摘要
对11名青少年类风湿性关节炎患儿的一些免疫参数进行了检测。观察到T淋巴细胞存在数量和功能缺陷，并伴有中性粒细胞趋化性缺陷。在11名患者中的5名患者血清中检测到高水平的循环免疫复合物。1名患者显示抗核抗体水平高且类风湿因子呈阳性。本文讨论了青少年类风湿性关节炎的免疫发病机制。
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