Blomquist H K, Gustavson K H, Holmgren G
J Ment Defic Res. 1981 Sep;25(Pt 3):169-86. doi: 10.1111/j.1365-2788.1981.tb00107.x.
A series of children with mild mental retardation (171 children, IQ 50-69) born in 1959-1970 in a northern Swedish county and registered by the Board for Provisions and Services to the Mentally Retarded were analysed retrospectively. The mean annual incidence of mild mental retardation in registered children alive at the age of one year decreased during the period 1959-1970 and for the whole period was 4.2 per 1000, compared with 3.9 per 1000 for severe mental retardation in the same period of time and area. Ten children once classified as mildly mentally retarded made considerable intellectual progress and after some time no longer needed special help from the authorities. There was a pronounced male excess in the total series (1.8:1) and in all the main aetiological groups. Only small differences were found in mean birth weights, gestational age and maternal age in the main aetiological groups. In the series as a whole, however, there was an increased frequency of children small for gestational age. Prenatal causes were considered relevant in 43 per cent, perinatal in 7 per cent, and postnatal in 5 per cent. In 2 per cent there was a psychosis. In 43 per cent the aetiology could not be traced. Genetic causes were found in 31 per cent; in 8 per cent there was a chromosomal aetiology, in a further 8 per cent a mutant gene disorder and in 15 per cent the aetiology were considered multifactorial, i.e. at least one first-degree relative also had mental retardation and in both cases the cause of the retardation was unknown. Thirty per cent of the children had associated CNS handicaps, epilepsy (16 per cent) being the most frequent.
对1959年至1970年出生在瑞典北部一个县、并由智障者供给与服务委员会登记在册的一系列轻度智力发育迟缓儿童(171名儿童,智商50 - 69)进行了回顾性分析。在1959年至1970年期间,一岁时存活的登记在册儿童中,轻度智力发育迟缓的年平均发病率有所下降,整个时期为每1000人中有4.2例,而在同一时期、同一地区,重度智力发育迟缓的发病率为每1000人中有3.9例。有10名曾被归类为轻度智力发育迟缓的儿童在智力方面取得了显著进步,一段时间后不再需要当局提供特殊帮助。在整个系列中,男性明显多于女性(1.8:1),在所有主要病因组中都是如此。在主要病因组中,平均出生体重、胎龄和母亲年龄仅有微小差异。然而,在整个系列中,小于胎龄儿的发生率有所增加。产前因素被认为相关的占43%,围产期因素占7%,产后因素占5%。2%的病例存在精神病。43%的病因无法追查。发现遗传病因的占31%;8%为染色体病因,另有8%为突变基因障碍,15%的病因被认为是多因素的,即至少有一名一级亲属也有智力发育迟缓,且两例智力发育迟缓的病因均不明。30%的儿童伴有中枢神经系统障碍,癫痫(16%)最为常见。