Safronova V M, Loktev N A, Afanas'ev E N, Taran I F, Lunina E A
Zh Mikrobiol Epidemiol Immunobiol. 1981 Jul(7):63-6.
In experiments on 240 guinea-pigs metabolic changes were found to occur in peripheral blood cells in the process of the development of brucellosis infection and after immunization. The degree and character of the activity of lysosomal enzymes depended on the time of infection and immunity formation. In comparison with the vaccinal culture of Br. abortus 19, the virulent culture of Br. abortus 544 induced greater changes in the activity of esterase, acidic and alkaline phosphatase in neutrophils, in the activity of acidic phosphatase in lymphocytes, as well as in the number of lymphocytes containing this enzyme. The data on enzymatic activity are recommended for use as a differential test for evaluating the character of the infectious and vaccinal processes.
在对240只豚鼠进行的实验中发现，在布鲁氏菌病感染发展过程中和免疫后，外周血细胞会发生代谢变化。溶酶体酶活性的程度和特征取决于感染时间和免疫形成时间。与流产布鲁氏菌19号疫苗株培养物相比，流产布鲁氏菌544强毒株培养物诱导中性粒细胞中酯酶、酸性和碱性磷酸酶活性、淋巴细胞中酸性磷酸酶活性以及含有该酶的淋巴细胞数量发生更大变化。建议将酶活性数据用作评估感染和疫苗接种过程特征的鉴别试验。
