Littner M R, Ulreich S, Putman C E, Rosenfield A T, Meadows G
AJR Am J Roentgenol. 1981 Sep;137(3):477-81. doi: 10.2214/ajr.137.3.477.
Pulmonary function (specifically, forced expiratory volume in 1 sec and forced expiratory flow at low lung volumes) was measured with maximal expiratory flow-volume curves during excretory urography in 70 patients and during sham procedures in 27 subjects. Forty-one patients received a 100 ml intravenous bolus of 60% methylglucamine diatrizoate and 29 patients received 100 ml of 50% sodium diatrizoate. Within 20 min, greater than 95% of patients had bronchospasm as indicated by asymptomatic decreases in pulmonary function. These decreases were significantly (p less than 0.001) greater than in the subjects undergoing sham procedures. Greater than 50% of patients had a maximum decrease in pulmonary function that exceeded the range of variability for consecutive repetitions of maximal expiratory flow-volume curves. These patients were classified as responders during excretory urography. The prevalence of responders was similar in methylglucamine diatrizoate and sodium diatrizoate patients. The magnitude of maximum decreases in pulmonary function did not differ significantly between methylglucamine diatrizoate and sodium diatrizoate responders.
Sodium diatrizoate does not offer an advantage over methylglucamine diatrizoate with respect to asymptomatic bronchospasm during excretory urography.
在70例患者排泄性尿路造影期间以及27名受试者假手术期间，使用最大呼气流量-容积曲线测量肺功能（具体为1秒用力呼气量和低肺容积时的用力呼气流量）。41例患者静脉推注100 ml 60%的泛影葡胺，29例患者静脉推注100 ml 50%的泛影钠。20分钟内，超过95%的患者出现支气管痉挛，表现为肺功能无症状下降。这些下降显著（p<0.001）大于接受假手术的受试者。超过50%的患者肺功能最大下降超过最大呼气流量-容积曲线连续重复测量的变异范围。这些患者在排泄性尿路造影期间被归类为反应者。泛影葡胺组和泛影钠组反应者的患病率相似。泛影葡胺组和泛影钠组反应者肺功能最大下降幅度无显著差异。
在排泄性尿路造影期间，就无症状支气管痉挛而言，泛影钠并不比泛影葡胺有优势。
