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[肌酸磷酸激酶(CPK)及其同工酶。与心肌损伤的相关性]

[Creatine phosphokinase (CPK) and isoenzymes. Correlation with myocardial damage].

作者信息

Zavala P, Schmidt G, Zavala V B

出版信息

Arch Inst Cardiol Mex. 1978 May-Jun;48(3):603-11.

PMID:697459
Abstract

1). The MB electrophoretic fraction of the serum CPK is specific in the diagnosis old acute myocardial infarction. 2). It allows us to differentiate ischaemia from myocardial necrosis. 3). The absence of this fraction, when found out during a period of 12 to 24 hours after the start of the angina attack allows us to deny the presence of acute myocardial infarction with a high index of precision. 4). Our results show that the serum sample should be obtained between 12 and 24 hours after starting the clinical case, in order to get a higher sensibility and specificity. 5). The quantification of MB fraction might be useful in the calculation of the amount of cardial muscle destroyed. When calculating the amount of cardial muscle destroyed of 125 cases (12.5%) with positive diagnosis of reinfarction and among the same 125, 12 were found occurring for the third time. Is possible that the real frequency of the iterative infarction is even higher, because many cases were dismissed (27.7%) for lack of electrocardiographic data, clearly pointing to myocardial transmural infarction. 6). Investigations were conduced about the evolutative condition of the danger factors.

摘要

1). 血清肌酸磷酸激酶(CPK)的MB电泳组分对陈旧性急性心肌梗死的诊断具有特异性。2). 它使我们能够区分心肌缺血和坏死。3). 在心绞痛发作开始后的12至24小时内若未发现该组分,可让我们以较高的准确性排除急性心肌梗死的存在。4). 我们的结果表明,为了获得更高的敏感性和特异性,血清样本应在临床症状出现后的12至24小时内采集。5). MB组分的定量可能有助于计算心肌受损量。在125例确诊为再梗死的病例(占12.5%)中计算心肌受损量时,在这125例中发现有12例是第三次发生。由于许多病例因缺乏心电图数据(明确显示为透壁性心肌梗死)而被排除(占27.7%),所以反复梗死的实际发生率可能更高。6). 对危险因素的演变情况进行了调查。

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