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[钙在正常张力性肌纤维收缩及去神经支配后的作用]

[Role of calcium in the contraction of normal tonic muscle fibers and following denervation].

作者信息

Lapshina I B, Nasledov G A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1981 Aug;67(8):1215-22.

PMID:6974659
Abstract

Studies in the frog isolated tonic muscle fibers revealed that change of the external calcium concentration normally has no effect on the magnitude of the potassium and caffeine contractures, whereas in denervated fibers a decrease of successively evoked potassium and caffeine contractures occurs in calcium-free solution. The adaptive relaxation of potassium contracture in denervated fibers accelerates with increase of potassium ions and decelerates with increase of calcium. Analysis of these phenomena suggests that: 1) the intracellular calcium alone participates in activation of contraction of these fibers, and 2) the effect of changes in external calcium concentration on the character of contraction is based on the calcium action upon the cell membrane rather than on changes of its amount.

摘要

对青蛙离体强直性肌纤维的研究表明,正常情况下,细胞外钙浓度的变化对钾和咖啡因挛缩的幅度没有影响,而在去神经纤维中,在无钙溶液中,相继诱发的钾和咖啡因挛缩会减小。去神经纤维中钾挛缩的适应性舒张随钾离子增加而加速,随钙增加而减速。对这些现象的分析表明:1)仅细胞内钙参与这些纤维收缩的激活,2)细胞外钙浓度变化对收缩特性的影响基于钙对细胞膜的作用,而非其含量的变化。

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1
[Role of calcium in the contraction of normal tonic muscle fibers and following denervation].[钙在正常张力性肌纤维收缩及去神经支配后的作用]
Fiziol Zh SSSR Im I M Sechenova. 1981 Aug;67(8):1215-22.
2
[Changes in the contractile properties of tonic muscle fibers following denervation].
Fiziol Zh SSSR Im I M Sechenova. 1978 Aug;64(8):1129-33.
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Selectivity of sodium channels in denervated tonic muscle fibre membrane of the frog.青蛙失神经支配的紧张性肌纤维膜中钠通道的选择性
Gen Physiol Biophys. 1983 Dec;2(6):425-35.
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[Nature of the dual caffeine-sodium benzoate effect on the tonic component of the potassium contracture of the myocardium in the frog].[咖啡因-苯甲酸钠二元混合物对青蛙心肌钾挛缩强直成分的作用性质]
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Caffeine contractures induced in frog auricular trabeculae in the absence of external calcium.在无细胞外钙的情况下,青蛙心耳小梁诱导产生咖啡因挛缩。
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Calcium dependence of potassium contractures in denervated frog muscle.
Am J Physiol. 1973 Jul;225(1):166-70. doi: 10.1152/ajplegacy.1973.225.1.166.
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Caffeine contractures in denervated frog muscle.失神经支配蛙肌中的咖啡因挛缩
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