妊娠小鼠的胸腺退化。I. 剩余胸腺细胞亚群的特征
Thymic involution in pregnant mice. I. Characterization of the remaining thymocyte subpopulations.
作者信息
Phuc L H, Papiernik M, Berrih S, Duval D
出版信息
Clin Exp Immunol. 1981 May;44(2):247-52.
Abstract
Pregnancy-induced thymic atrophy was studied in mice during the course of syngeneic gestation and the post-partum period. Cortical thymocytes were greatly reduced in number as shown by the binding of fluorescein-labelled PNA. The pool of steroid-resistant (SR) medullary thymocytes appeared unchanged in pregnant mice when studied by means of a specific heteroantiserum (SRCA). Therefore, in pregnant mice, these two surface markers demonstrated that thymic atrophy was linked to steroid-sensitive (SS) cortical cell reduction. The presumed hydrocortisone resistance of the mother's remaining thymocytes is not related to a difference in the number of steroid receptors as determined by 3H-dexamethasone binding.
摘要
在同基因妊娠及产后期间，对小鼠的妊娠诱导性胸腺萎缩进行了研究。如荧光素标记的PNA结合所示，皮质胸腺细胞数量大幅减少。通过特异性异种抗血清（SRCA）研究发现，妊娠小鼠中类固醇抗性（SR）髓质胸腺细胞池似乎未发生变化。因此，在妊娠小鼠中，这两种表面标志物表明胸腺萎缩与类固醇敏感（SS）皮质细胞减少有关。通过3H-地塞米松结合测定，母亲剩余胸腺细胞的假定氢化可的松抗性与类固醇受体数量的差异无关。
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