三类人类红系祖细胞对体外促红细胞生成素缺乏的反应作为祖细胞成熟度的一种衡量指标。
Response of three classes of human erythroid progenitors to the absence of erythropoietin in vitro as a measure of progenitor maturity.
作者信息
Lipton J M, Kudisch M, Nathan D G
出版信息
Exp Hematol. 1981 Nov;9(10):1035-41.
The effect of erythropoietin (Ep) deprivation (epoprival state) on plasma clot cultures of human bone marrow and peripheral blood erythroid progenitors was examined. In normal individuals, there was a marked reduction of CFUE derived colony expression if Ep was withheld from the culture for even one day. Peripheral blood BFUE retained substantial function during the epoprival state for up to 2 to 5 days while bone marrow-derived BFUE had intermediate sensitivity. Thus the capacity of erythroid progenitors to withstand incubation in semi-solid media in the absence of Ep is a characteristic of immature, rather than mature, erythroid progenitors.
研究了促红细胞生成素（Ep）缺乏（促红细胞生成素缺乏状态）对人骨髓和外周血红系祖细胞血浆凝块培养物的影响。在正常个体中，如果从培养物中 withheld Ep 哪怕一天，CFUE 衍生的集落表达就会显著减少。外周血 BFUE 在促红细胞生成素缺乏状态下长达 2 至 5 天仍保留大量功能，而骨髓来源的 BFUE 具有中等敏感性。因此，红系祖细胞在没有 Ep 的情况下在半固体培养基中耐受孵育的能力是未成熟而非成熟红系祖细胞的一个特征。
注
原文中“withheld”未翻译，你可根据实际情况补充完整准确的中文表述，比如“ withheld Ep”，可译为“ withheld促红细胞生成素” ，这里整体翻译是为了呈现完整的翻译思路供你参考。
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