Anti-self receptors. III. Lack of allelic exclusion and thymic epithelium dependence of H-2L-region-restricted receptors on lymphocytes.

Murine thymocytes and peripheral lymphocytes bind autologous erythrocytes via H-2L-region-restricted receptors. After inhibiting autorosetting with different erythrocyte sonicates the specificity of these anti-self receptors was examined in F1 hybrid and chimaeric mice. Most F1 lymphocytes simultaneously expressed receptors against both parental haplotypes. Furthermore, analysis of lymphocytes from allogeneic and semi-allogeneic chimaeras clearly demonstrated that radioresistant elements in the recipient thymus did not modify the haplotype specificity of the receptors on donor-derived lymphocytes.